NASA's Wide-field Infrared Survey Explorer (WISE; Wright et al. 2010) mapped the sky at 3.4, 4.6, 12, and 22 μm (W1, W2, W3, W4) in 2010 with an angular resolution of 6.1", 6.4", 6.5", & 12.0" in the four bands. WISE achieved 5σ point source sensitivities better than 0.08, 0.11, 1 and 6 mJy in unconfused regions on the ecliptic in the four bands. Sensitivity improves toward the ecliptic poles due to denser coverage and lower zodiacal background. The All-Sky Release includes all data taken during the WISE full cryogenic mission phase, 7 January 2010 to 6 August 2010, that were processed with improved calibrations and reduction algorithms. Release data products include an Atlas of 18,240 match-filtered, calibrated and coadded image sets, a Source Catalog containing positional and photometric information for over 563 million objects detected on the WISE images, and an Explanatory Supplement that is a guide to the format, content, characteristics and cautionary notes for the WISE All-Sky Release products. The WISE All-Sky Data Release products supersede those from the April 2011 Preliminary Data Release. All-Sky Release ancillary products include a Reject Table containing 284 million detections that were not selected for inclusion in the Source Catalog because they are low signal-to-noise ratio or spurious detections of image artifacts, an archive of over 1.5 million Single-exposure Image sets and a database of over 9.4 billion source extractions from those images, and moving object tracklets identified as part of the NEOWISE program (Mainzer et al. 2011). Here we only provide catalog data.